Pre_GI: BLASTP Hits

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Query: NC_004337:2478461:2498102 Shigella flexneri 2a str. 301, complete genome

Start: 2498102, End: 2498344, Length: 243

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:2516000:253574425357442535986243Shigella flexneri 2002017 chromosome, complete genomeinner membrane protein3e-38157
NC_008258:2473000:249184224918422492084243Shigella flexneri 5 str. 8401, complete genomehypothetical protein3e-38157
CU928160:2513000:253195525319552532197243Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein; putative inner membrane protein3e-38157
CP002185:2659628:267950626795062679748243Escherichia coli W, complete genomepredicted inner membrane protein3e-38157
NC_010468:1412791:141579414157941416036243Escherichia coli ATCC 8739, complete genomehypothetical protein3e-38157
AP010958:2911741:294604429460442946286243Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted inner membrane protein3e-38157
NC_004741:2456297:247624024762402476482243Shigella flexneri 2a str. 2457T, complete genomehypothetical protein3e-38157
NC_007606:2353098:237227623722762372518243Shigella dysenteriae Sd197, complete genomehypothetical protein3e-38157
NC_007384:2587876:260820726082072608449243Shigella sonnei Ss046, complete genomehypothetical protein3e-38157
NC_010658:2529033:254974425497442549986243Shigella boydii CDC 3083-94, complete genomehypothetical protein3e-38157
CP002516:1419413:142610914261091426351243Escherichia coli KO11, complete genomehypothetical protein3e-38157
NC_016902:1419413:142610914261091426351243Escherichia coli KO11FL chromosome, complete genomehypothetical protein3e-38157
NC_016822:2678691:270028927002892700531243Shigella sonnei 53G, complete genomehypothetical protein3e-38157
NC_013353:2911741:294604429460442946286243Escherichia coli O103:H2 str. 12009, complete genomeinner membrane protein3e-38157
NC_012967:2409500:242927424292742429516243Escherichia coli B str. REL606 chromosome, complete genomeputative inner membrane protein3e-38157
NC_012947:1363724:136672713667271366969243Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein3e-38157
NC_011741:2513000:253195525319552532197243Escherichia coli IAI1 chromosome, complete genomehypothetical protein3e-38157
NC_009800:2505872:252645225264522526694243Escherichia coli HS, complete genomehypothetical protein3e-38157
NC_008253:2499735:251847825184782518720243Escherichia coli 536, complete genomehypothetical protein YfdY1e-37155
NC_011601:2614691:265145826514582651700243Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein1e-37155
NC_011742:2533500:255194925519492552191243Escherichia coli S88 chromosome, complete genomehypothetical protein1e-37155
NC_011353:3276734:332729933272993327541243Escherichia coli O157:H7 str. EC4115 chromosome, complete genomehypothetical protein9e-38155
NC_013941:2928000:296425329642532964495243Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein9e-38155
NC_009801:2639787:265855626585562658798243Escherichia coli E24377A, complete genomehypothetical protein6e-38155
NC_007613:2376974:239697923969792397221243Shigella boydii Sb227, complete genomehypothetical protein1e-37154
NC_011745:2751437:276978827697882770030243Escherichia coli ED1a chromosome, complete genomehypothetical protein3e-37153
NC_011740:810411:810411810411810659249Escherichia fergusonii ATCC 35469, complete genomehypothetical protein4e-29126
NC_003198:2453074:247369724736972473939243Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein2e-25114
NC_011205:2621415:263993726399372640179243Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein2e-25114
NC_011274:2483038:250374825037482503990243Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91hypothetical protein2e-25114
NC_011294:2492168:251284925128492513091243Salmonella enterica subsp. enterica serovar Enteritidis strhypothetical protein2e-25114
NC_015761:2373967:239413423941342394376243Salmonella bongori NCTC 12419, complete genomehypothetical protein7e-24109
NC_020063:2230000:223638622363862236631246Enterobacteriaceae bacterium strain FGI 57, complete genomeProtein of unknown function (DUF2545)3e-1063.5