Pre_GI Gene

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Host: NC_000962 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000962:1684005 Mycobacterium tuberculosis H37Rv, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
168400516862572253methylmalonyl-CoA mutaseQuickGO ontologyBLASTP
16862711686573303hypothetical proteinBLASTP
16865701686887318hypothetical proteinBLASTP
168688416878881005arginineornithine transport system ATPaseQuickGO ontologyBLASTP
168794116892301290PROBABLE ESTERASE LIPLQuickGO ontologyBLASTP
16901341690346213hypothetical proteinBLASTP
16904071690805399hypothetical proteinBLASTP
16918901692711822hypothetical proteinBLASTP
16929241693823900hypothetical proteinBLASTP
16939961694544549hypothetical proteinBLASTP
16945451695144600hypothetical proteinBLASTP
16952811695946666hypothetical proteinBLASTP
16959431696443501hypothetical proteinBLASTP
16967271697422696hypothetical proteinBLASTP
16973561697859504hypothetical proteinBLASTP
169809516998941800Probable membrane proteinQuickGO ontologyBLASTP
16998661700228363hypothetical proteinBLASTP
17002121701093882hypothetical proteinBLASTP
170129517025931299conserved probable membrane proteinQuickGO ontologyBLASTP
170307417040961023GDP-D-mannose dehydratase gmdA GDP-mannose 46 dehydratase GMDQuickGO ontologyBLASTP
17040931705061969probable nucleotide-sugar epimerase epiAQuickGO ontologyBLASTP
17050581705789732hypothetical proteinBLASTP
17058071706595789hypothetical proteinBLASTP
17066301707526897hypothetical proteinBLASTP
170752917085391011probable sugar transferaseQuickGO ontologyBLASTP