Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_000962: Mycobacterium tuberculosis H37Rv, complete genome

NCBI: NC_000962

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
147581649961923804Island text1.8265718.723529.9193Neighbours11BLASTN+475816.gbk
21095078*111574920672Island text1.6055119.050326.343Neighbours11BLASTN+IslandViewer 1095078.gbk
31684005170853924535Island text2.0203321.504121.6182Neighbours11BLASTN+1684005.gbk
41870842189534224501Island text1.7496720.226136.0589Neighbours11BLASTN+1870842.gbk
52791019281491123893Island text1.4850118.385222.451Neighbours11BLASTN2791019.gbk
63116818313633319516Island text1.5140920.868833.6627Neighbours11BLASTN+IslandViewer 3116818.gbk
73288464331029721834Island text1.54516.725431.3132Neighbours11BLASTN+3288464.gbk
83474000349418120182Island text1.5450217.232116.1814NeighboursBLASTN+IslandViewer 3474000.gbk
93781501380757326073Island text1.4948516.050617.7732Neighbours11BLASTN+IslandViewer 3781501.gbk