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Query: NC_009089:1093832:1099200 Clostridium difficile 630, complete genome

Start: 1099200, End: 1100039, Length: 840

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome4e-151533
NC_018704:176088:1952841952841963331050Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein1e-47190
NC_012658:2525931:253679425367942537750957Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage protein4e-47188
NC_020272:1311932:132471213247121325584873Bacillus amyloliquefaciens IT-45, complete genomeDnaA like protein, DnaD domain protein2e-46186
NC_015660:739040:748842748842749696855Geobacillus thermoglucosidasius C56-YS93 chromosome, completeprimosome, DnaD subunit8e-40164
NC_013171:896802:902461902461903405945Anaerococcus prevotii DSM 20548, complete genomehypothetical protein3e-23108
NC_014657:914071:914071914071915021951Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein1e-1583.6
NC_006582:2944237:298357029835702984349780Bacillus clausii KSM-K16, complete genomephage replication protein5e-1478.6
NC_014721:2135500:2155658215565821574721815Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehypothetical protein8e-1064.3
NC_012856:3000839:300946630094663010413948Ralstonia pickettii 12D chromosome 1, complete genomehypothetical protein1e-0653.9
NC_014355:3951855:395842439584243959122699Candidatus Nitrospira defluvii, complete genomehypothetical protein1e-0653.5
NC_010682:3313944:334801233480123348965954Ralstonia pickettii 12J chromosome 1, complete sequencehypothetical protein2e-0653.5