Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:2525931 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25257682525968201hypothetical proteinBLASTP
25259312526095165hypothetical proteinBLASTP
252619625272841089Ig group 2 domain-containing proteinQuickGO ontologyBLASTP
25276202528057438hypothetical proteinBLASTP
25280682528286219hypothetical protein
25282832528474192hypothetical proteinBLASTP
25285642528890327hypothetical protein
25289052529897993phage integraseQuickGO ontologyBLASTP
25299802530129150hypothetical protein
25304922530824333hypothetical proteinBLASTP
25308332531651819hypothetical proteinBLASTP
25316442531811168hypothetical proteinBLASTP
25318232532611789hypothetical proteinBLASTP
25326302533259630hypothetical proteinBLASTP
25332472533669423hypothetical proteinBLASTP
25336662533827162hypothetical proteinBLASTP
25339182534268351MazG nucleotide pyrophosphohydrolase domain familyQuickGO ontologyBLASTP
25342852534404120hypothetical protein
25344112534722312hypothetical proteinBLASTP
25347522535747996hypothetical proteinBLASTP
25357602535993234hypothetical proteinBLASTP
25360132536801789hypothetical proteinBLASTP
25367942537750957phage proteinQuickGO ontologyBLASTP
25377842538023240hypothetical proteinBLASTP
25381772538353177hypothetical proteinBLASTP
25383692538515147hypothetical proteinBLASTP
25385182539402885RecTQuickGO ontologyBLASTP
253941525404641050putative YqaJQuickGO ontologyBLASTP
25407202540884165hypothetical proteinBLASTP
25408932541051159hypothetical proteinBLASTP
25411042541256153hypothetical proteinBLASTP
25412772541486210hypothetical proteinBLASTP
25415542541889336hypothetical protein
25420652542292228hypothetical protein
25422932543156864anti-repressorQuickGO ontologyBLASTP
25432142543453240hypothetical proteinBLASTP