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Query: NC_008593:1362218:1379197 Clostridium novyi NT, complete genome

Start: 1379197, End: 1379793, Length: 597

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:131409513140951314709615Clostridium botulinum BKT015925 chromosome, complete genomescaffold protein6e-49193
NC_010001:3614314:363019736301973630799603Clostridium phytofermentans ISDg, complete genomehypothetical protein1e-23109
NC_011898:3567761:359143435914343592015582Clostridium cellulolyticum H10, complete genomeminor structural GP20 protein3e-1581.6
NC_011898:3824000:383985938398593840440582Clostridium cellulolyticum H10, complete genomeminor structural GP20 protein4e-1581.3
NC_004668:295417:312473312473313045573Enterococcus faecalis V583, complete genomescaffold protein1e-1480.1
NC_014376:1472304:149697214969721497565594Clostridium saccharolyticum WM1 chromosome, complete genomeminor structural GP20 protein5e-1167.4
NC_015737:53682:652876528765922636Clostridium sp. SY8519, complete genomehypothetical protein1e-0653.1