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Query: NC_004741:3240909:3252275 Shigella flexneri 2a str. 2457T, complete genome

Start: 3252275, End: 3252439, Length: 165

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:3289853:330121933012193301383165Shigella flexneri 2002017 chromosome, complete genomehypothetical protein7e-24108
NC_011741:3344746:335612433561243356288165Escherichia coli IAI1 chromosome, complete genomehypothetical protein9e-1889
NC_011415:3523364:353768635376863537850165Escherichia coli SE11 chromosome, complete genomehypothetical protein9e-1889
CU928160:3344746:335612433561243356288165Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein9e-1889
NC_007613:2981829:299251729925172992681165Shigella boydii Sb227, complete genomehypothetical protein9e-1889
NC_009801:3595001:360454036045403604704165Escherichia coli E24377A, complete genomehypothetical protein9e-1889