Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:3289853 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
328985332912231371putative L-serine deaminaseQuickGO ontologyBLASTP
32912893291741453hypothetical proteinBLASTP
329169232939862295Keto-acid formate acetyltransferaseQuickGO ontologyBLASTP
329402032952401221putative kinaseQuickGO ontologyBLASTP
329525432965851332Threonineserine transporter tdcC Hthreonine-serine symporterQuickGO ontologyBLASTP
32966073297596990Threonine dehydratase catabolicQuickGO ontologyBLASTP
32976953298633939HTH-type transcriptional regulator tdcAQuickGO ontologyBLASTP
32988233299167345Threonine dehydratase operon activator proteinQuickGO ontologyBLASTP
33012193301383165hypothetical proteinBLASTP
33017743302253480hypothetical proteinBLASTP
330218133034071227glycerate kinaseQuickGO ontologyBLASTP
33034233304229807putative dehydrogenaseQuickGO ontologyBLASTP
330513033064641335putative galactarate transporterQuickGO ontologyBLASTP
33066733306792120hypothetical proteinBLASTP
330683933084101572putative hydrolaseQuickGO ontologyBLASTP
33084623309286825putative DEOR-type transcriptional regulator of aga operonQuickGO ontologyBLASTP
330953533108151281putative tagatose 6-phosphate kinase 2QuickGO ontologyBLASTP
33108023311311510PTS system cytoplasmic N-acetylgalactosamine-specific IIB component 2QuickGO ontologyBLASTP
331132233127791458PTS system N-acetylgalactosamine-specific transporter subunit IIDQuickGO ontologyBLASTP