Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:2981829 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29818292982281453hypothetical proteinBLASTP
298223229845262295probable formate acetyltransferase 3QuickGO ontologyBLASTP
298456029857801221putative kinaseQuickGO ontologyBLASTP
298579429871251332anaerobically inducible L-threonine L-serine permeaseQuickGO ontologyBLASTP
29871472988136990threonine dehydratase catabolicQuickGO ontologyBLASTP
29882352989173939transcriptional activator of tdc operonQuickGO ontologyBLASTP
29893622989706345threonine dehydratase operon activator proteinQuickGO ontologyBLASTP
29899982990288291putative IS1 encoded proteinQuickGO ontologyBLASTP
29903812990884504IS1 ORF2QuickGO ontologyBLASTP
29916932992484792hypothetical proteinBLASTP
29925172992681165hypothetical proteinBLASTP
299325329944791227hypothetical proteinBLASTP
29944952995394900putative dehydrogenaseQuickGO ontologyBLASTP
29954152996185771hypothetical proteinBLASTP
29975352998038504IS1 ORF2QuickGO ontologyBLASTP
299885929998991041putative reductaseQuickGO ontologyBLASTP
29999393000433495hypothetical proteinBLASTP
30006243001508885putative oxidoreductaseQuickGO ontologyBLASTP
30016843001929246hypothetical protein
30017803002205426ExbDQuickGO ontologyBLASTP
30022123002946735ExbBQuickGO ontologyBLASTP
30029393003094156hypothetical protein
300319830043851188cystathionine beta-lyaseQuickGO ontologyBLASTP