Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2740870 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
274087027424531584NADH dehydrogenase I subunit CDQuickGO ontologyBLASTP
27424562743019564ATP synthase subunit EQuickGO ontologyBLASTP
274301627444011386NADH dehydrogenase I subunit FQuickGO ontologyBLASTP
274448827472322745NADH dehydrogenase subunit gammaQuickGO ontologyBLASTP
27472292748206978NADH dehydrogenase subunit HQuickGO ontologyBLASTP
27482212748763543NADH dehydrogenase subunit IQuickGO ontologyBLASTP
27487762749321546NADH dehydrogenase subunit JQuickGO ontologyBLASTP
27493182749620303NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
274961727514611845NADH dehydrogenase subunit LQuickGO ontologyBLASTP
275150127530331533NADH dehydrogenase subunit MQuickGO ontologyBLASTP
275304027545031464NADH dehydrogenase subunit NQuickGO ontologyBLASTP
275473927559291191hypothetical proteinBLASTP
27562672756734468hypothetical proteinBLASTP
27568122757348537putative thermosensitive gluconokinaseQuickGO ontologyBLASTP
27573972758161765gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
275892027602031284putative lipoproteinQuickGO ontologyBLASTP