Pre_GI Gene

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Host: NC_015571 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015571:722815 Porphyromonas gingivalis TDC60, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
722815723570756succinate dehydrogenasefumarate reductase iron-sulfur subunitQuickGO ontologyBLASTP
723803724207405glyoxalase family proteinQuickGO ontologyBLASTP
7243067258591554methylmalonyl-CoA decarboxylase subunit alphaQuickGO ontologyBLASTP
725884726825942hypothetical proteinBLASTP
726822727058237hypothetical protein
727096727530435methylmalonyl-CoA decarboxylase gamma subunitQuickGO ontologyBLASTP
7275357286861152methylmalonyl-CoA decarboxylase subunit betaQuickGO ontologyBLASTP
729353729490138hypothetical protein
730175730345171hypothetical protein
7305597332972739metal dependent phosphohydrolaseQuickGO ontologyBLASTP
7338387352411404aminopeptidase CQuickGO ontologyBLASTP
7352937376232331immunoreactive 84 kDa antigen PG93QuickGO ontologyBLASTP
737611738195585putative deoxyribonucleoside-triphosphataseQuickGO ontologyBLASTP
738266738646381hypothetical proteinBLASTP
738618739391774biotin--acetyl-CoA-carboxylase ligaseQuickGO ontologyBLASTP
7394267404511026hypothetical proteinBLASTP
740485741273789hypothetical proteinBLASTP
741270741950681lipoprotein signal peptidaseQuickGO ontologyBLASTP
741954742334381putative DnaK suppressor proteinQuickGO ontologyBLASTP
7424047458173414isoleucyl-tRNA synthetaseQuickGO ontologyBLASTP