Pre_GI Gene

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Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:767940 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7679407690281089ATPaseQuickGO ontologyBLASTP
771548771853306hypothetical proteinBLASTP
771859772806948quinone oxidoreductaseQuickGO ontologyBLASTP
773600773899300nucleotidyltransferaseQuickGO ontologyBLASTP
773892774335444nucleotidyltransferaseQuickGO ontologyBLASTP
774494774745252hypothetical proteinBLASTP
774997775215219hypothetical proteinBLASTP
775256775525270hypothetical proteinBLASTP
7757897769311143hypothetical ATPaseQuickGO ontologyBLASTP
777046777198153hypothetical proteinBLASTP
777497778042546hypothetical cytosolic proteinQuickGO ontologyBLASTP
778508778702195hypothetical membrane-associated proteinQuickGO ontologyBLASTP
77945177952171tRNA-CysQuickGO ontology
7821207835321413lignostilbene-alphabeta-dioxygenaseQuickGO ontologyBLASTP
783583783897315hypothetical proteinBLASTP
783894784268375CrcB family proteinQuickGO ontologyBLASTP
7842697855971329adenosylmethionine-8-amino-7-oxononanoate aminotransferaseQuickGO ontologyBLASTP
785966786931966biotin synthaseQuickGO ontologyBLASTP
78691878807211558-amino-7-oxononanoate synthaseQuickGO ontologyBLASTP
788066788770705carboxylesteraseQuickGO ontologyBLASTP
788760789506747biotin synthesis proteinQuickGO ontologyBLASTP
789503790231729dethiobiotin synthetaseQuickGO ontologyBLASTP
790159791130972biotin operon repressorQuickGO ontologyBLASTP