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Query: NC_011528:767940:788066 Coxiella burnetii CbuK_Q154, complete genome

Start: 788066, End: 788770, Length: 705

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002971:951102:950404950404951108705Coxiella burnetii RSA 493, complete genomebioH protein4e-121434
NC_009727:1001203:102223510222351022939705Coxiella burnetii Dugway 7E9-12, complete genomeputative carboxylesterase BioH4e-121434
NC_011527:953442:974255974255974959705Coxiella burnetii CbuG_Q212, complete genomecarboxylesterase4e-120430
NC_015554:4824000:484387648438764844697822Alteromonas sp. SN2 chromosome, complete genomeputative bioH protein7e-1580.9
NC_007484:2392739:241300224130022413769768Nitrosococcus oceani ATCC 19707, complete genomebiotin biosynthesis protein, BioH5e-1374.7
NC_006370:166000:182815182815183579765Photobacterium profundum SS9 chromosome 1, complete sequenceputative bioH protein2e-1272.8
NC_009052:144619:161267161267161989723Shewanella baltica OS155, complete genomebioH protein2e-1065.9
NC_007086:459934:459934459934460695762Xanthomonas campestris pv. campestris str. 8004, complete genomebiotin biosynthesis protein2e-0756.2
NC_017271:4410500:443231044323104433092783Xanthomonas campestris pv. raphani 756C chromosome, completeputative pimeloyl-BioC--CoA transferase BioH3e-0755.5
NC_009465:766893:800243800243800980738Candidatus Vesicomyosocius okutanii HA, complete genomebiotin biosynthesis protein BioH1e-0653.9