Pre_GI Gene

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Host: NC_011527 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011527:1255998 Coxiella burnetii CbuG_Q212, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12570801257856777polysaccharide export ATP-binding proteinQuickGO ontologyBLASTP
12578661258729864O-antigen export system permease proteinQuickGO ontologyBLASTP
125873912594887503-oxoacyl-acyl-carrier protein reductaseQuickGO ontologyBLASTP
12596251260458834325-bisphosphate nucleotidaseQuickGO ontologyBLASTP
126044012621971758sulfate adenylyltransferaseQuickGO ontologyBLASTP
126223312637921560sulfotransferaseQuickGO ontologyBLASTP
126399412651631170hypothetical proteinBLASTP
126518612663461161dTDP-4-dehydro-6-deoxy-D-glucose 4-aminotransferaseQuickGO ontologyBLASTP
126637712675311155nucleotide-sugar aminotransferaseQuickGO ontologyBLASTP
126752412689001377hypothetical proteinBLASTP
126896212700741113glycosyltransferaseQuickGO ontologyBLASTP
127020112712501050pyruvate dehydrogenase E1 component alpha subunitQuickGO ontologyBLASTP
127124712723081062pyruvate dehydrogenase E1 component beta subunitQuickGO ontologyBLASTP
127232912735671239methyltransferaseQuickGO ontologyBLASTP
12735601274417858polyprenyl-phosphate beta-D-mannosyltransferaseQuickGO ontologyBLASTP
127442612754721047GDP-mannose 46 dehydrataseQuickGO ontologyBLASTP
12754651276463999GDP-L-fucose synthaseQuickGO ontologyBLASTP
127684312784861644hypothetical exported membrane spanning proteinQuickGO ontologyBLASTP
128321612846341419sulfotransferaseQuickGO ontologyBLASTP
128497112862841314hypothetical proteinBLASTP
12862291286882654methyltransferaseQuickGO ontologyBLASTP
12868851287790906NAD dependent epimerasedehydratase familyQuickGO ontologyBLASTP
128778312890931311UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
12890781290022945NADH-dependent dehydrogenaseQuickGO ontologyBLASTP