Pre_GI Gene

Some Help

Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:588137 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
587203588153951siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
5881375892071071siderophore biosynthesis protein IucA famillyQuickGO ontologyBLASTP
589300589908609hypothetical proteinBLASTP
5900485912711224hypothetical proteinBLASTP
591561592394834hypothetical proteinBLASTP
5927715941291359hypothetical proteinBLASTP
594691595434744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
595415596065651N-acylhomoserine lactone synthase YspIQuickGO ontologyBLASTP
597610597891282membrane proteinQuickGO ontologyBLASTP
598342598737396putative lipoproteinQuickGO ontologyBLASTP
598805599068264insertion element proteinQuickGO ontologyBLASTP
601013601513501hypothetical proteinBLASTP
6015626031061545hypothetical proteinBLASTP
6031186044701353hypothetical proteinBLASTP
604467605153687membrane proteinQuickGO ontologyBLASTP
6051536068891737OmpA-family membrane proteinQuickGO ontologyBLASTP
606866607351486hypothetical proteinBLASTP
606893607384492hypothetical proteinBLASTP