Pre_GI: BLASTP Hits

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Query: NC_009381:588137:606866 Yersinia pestis Pestoides F chromosome, complete genome

Start: 606866, End: 607351, Length: 486

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004088:2966331:298490029849002985385486Yersinia pestis KIM, complete genomehypothetical protein3e-69260
NC_004088:3689000:370818637081863708671486Yersinia pestis KIM, complete genomehypothetical protein3e-69260
NC_009381:1682000:170223317022331702718486Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein4e-68256