Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:4053363 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
405336340544931131oxidoreductaseQuickGO ontologyBLASTP
40544904055389900hypothetical proteinBLASTP
40557364056530795hypothetical proteinBLASTP
405653940610774539membrane proteinQuickGO ontologyBLASTP
40611224061544423hypothetical proteinBLASTP
406154740637452199Rhs accessory genetic elementQuickGO ontologyBLASTP
40637674063943177hypothetical proteinBLASTP
40641064064513408transcriptional regulatory proteinQuickGO ontologyBLASTP
40645954064819225hypothetical proteinBLASTP
40648954065086192hypothetical proteinBLASTP
40651364065621486hypothetical proteinBLASTP
406562340669931371hypothetical proteinBLASTP
406702140698852865hypothetical proteinBLASTP
40698784070336459hypothetical proteinBLASTP
407034240727442403Rhs accessory genetic elementQuickGO ontologyBLASTP