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Query: NC_008149:4053363:4054490 Yersinia pestis Nepal516, complete genome

Start: 4054490, End: 4055389, Length: 900

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017160:4073611:407473840747384075637900Yersinia pestis D182038 chromosome, complete genomehypothetical protein2e-176617
NC_005810:4469156:446915644691564470055900Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-176617
NC_010634:4234932:423605942360594236958900Yersinia pseudotuberculosis PB1/+, complete genomexylose isomerase domain-containing protein2e-176617
NC_004088:266543:267670267670268569900Yersinia pestis KIM, complete genomehypothetical protein2e-176617
NC_014532:2298628:231176323117632312605843Halomonas elongata DSM 2581, complete genomehypothetical protein6e-26118
NC_012780:430653:452766452766453626861Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequencehypothetical protein6e-1788.2
NC_012034:390273:393814393814394752939Anaerocellum thermophilum DSM 6725, complete genomeXylose isomerase domain protein TIM barrel1e-0963.9
NC_014392:355443:358952358952359890939Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeXylose isomerase domain-containing protein TIM barrel1e-0963.9
NC_015520:2859820:286569128656912866545855Mahella australiensis 50-1 BON chromosome, complete genomexylose isomerase domain-containing protein4e-0652.4