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Query: NC_008149:4053363:4055736 Yersinia pestis Nepal516, complete genome

Start: 4055736, End: 4056530, Length: 795

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017160:4073611:407598440759844076778795Yersinia pestis D182038 chromosome, complete genomehypothetical protein5e-146516
NC_004088:266543:268916268916269710795Yersinia pestis KIM, complete genomehypothetical protein5e-146516
NC_005810:4469156:447172544717254472519795Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein5e-146516
NC_010501:2796000:280587028058702806655786Pseudomonas putida W619, complete genomehypothetical protein7e-58224
NC_017986:5605197:562389156238915624676786Pseudomonas putida ND6 chromosome, complete genomehypothetical protein8e-54210
NC_010552:2089140:209665320966532097450798Burkholderia ambifaria MC40-6 chromosome 2, complete sequencehypothetical protein1e-36153