Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3724829 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
372482937261301302cell division protein ftsaQuickGO ontologyBLASTP
37265033727300798cell division protein ftsqQuickGO ontologyBLASTP
37273993728304906UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
372836637294601095N-acetylglucosaminyl transferaseQuickGO ontologyBLASTP
372956637306571092stage v sporulation protein eQuickGO ontologyBLASTP
373074837321001353UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
37321013733075975phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
373309837345731476UDP-N-acetylmuramoylalanyl-D-glutamate--2 6-diaminopimelate ligaseQuickGO ontologyBLASTP
373478237366981917sporulation specific penicillin-binding proteinQuickGO ontologyBLASTP
373678037389302151penicillin-binding proteinQuickGO ontologyBLASTP
37389523739314363cell division protein ftslQuickGO ontologyBLASTP
37393303740262933S-adenosyl-methyltransferase MraWQuickGO ontologyBLASTP
374063337422491617hypothetical proteinBLASTP
374232937432138852-dehydropantoate 2-reductaseQuickGO ontologyBLASTP
37437903744263474acetyltransferase gnat familyQuickGO ontologyBLASTP
37442983744804507dna-binding protein putativeQuickGO ontologyBLASTP
3744933374510617450S ribosomal protein L32QuickGO ontologyBLASTP
37451683745668501hypothetical proteinBLASTP
37460853746681597prophage lambdaba02 lipoprotein putativeQuickGO ontologyBLASTP
37467143747337624hypothetical proteinBLASTP
374727937484601182prophage lambdaba02 ftskspoiiie family proteinQuickGO ontologyBLASTP