Pre_GI: BLASTP Hits

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Query: NC_007530:3724829:3740633 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 3740633, End: 3742249, Length: 1617

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3724729:3740533374053337421491617Bacillus anthracis str. A0248, complete genomehypothetical protein01062
NC_005945:3725397:3741201374120137428171617Bacillus anthracis str. Sterne, complete genomehypothetical protein01062
NC_003997:3724702:3740506374050637421221617Bacillus anthracis str. Ames, complete genomehypothetical protein01062
NC_005957:3746891:3762701376270137643171617Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein01046
NC_014335:3675456:3691266369126636928821617Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein01046
NC_011969:3657360:3673169367316936747851617Bacillus cereus Q1 chromosome, complete genomehypothetical protein01040
NC_006274:3805134:3820944382094438225601617Bacillus cereus E33L, complete genomehypothetical protein01038
NC_016771:3665773:3681581368158136831971617Bacillus cereus NC7401, complete genomehypothetical protein01036
NC_004722:3886800:3902736390273639043521617Bacillus cereus ATCC 14579, complete genomehypothetical Membrane Spanning Protein0996
NC_014171:3812247:3825604382560438272201617Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein0995
NC_011725:3928853:3944787394478739464031617Bacillus cereus B4264 chromosome, complete genomehypothetical protein0993
NC_017208:3928161:3942389394238939440051617Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein0993
NC_011772:3896635:3910812391081239124281617Bacillus cereus G9842, complete genomehypothetical protein0989
NC_007503:1680513:1700823170082317024301608Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein2e-56220
NC_017045:1579596:1597334159733415989141581Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,hypothetical protein6e-33142
NC_020125:288706:2906392906392922191581Riemerella anatipestifer RA-CH-2, complete genomehypothetical protein6e-33142