Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:1459412 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14594121460179768menaquinol-cytochrome c reductase cytochrome bc subunitQuickGO ontologyBLASTP
1460222146031493hypothetical protein
14603081460892585hypothetical proteinBLASTP
14609181461604687hypothetical proteinBLASTP
14617121462500789hypothetical proteinBLASTP
14626131463293681hypothetical proteinBLASTP
14633951464036642uracil-dna glycosylase family proteinQuickGO ontologyBLASTP
14640651464946882hypothetical proteinBLASTP
14652991465670372hypothetical proteinBLASTP
14656701466470801dihydrodipicolinate reductaseQuickGO ontologyBLASTP
14664851466880396methylglyoxal synthaseQuickGO ontologyBLASTP
14668921467596705hypothetical proteinBLASTP
146759314687381146glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
146872514699181194polya polymeraseQuickGO ontologyBLASTP
14699031470883981bira bifunctional proteinQuickGO ontologyBLASTP
14709841471373390hypothetical proteinBLASTP
147178014726198403-methyl-2-oxobutanoate hydroxymethyltransferaseQuickGO ontologyBLASTP
14726161473464849pantoate--beta-alanine ligaseQuickGO ontologyBLASTP
14734771473860384aspartate 1-decarboxylase precursorQuickGO ontologyBLASTP
147398914767932805ATP-dependent DNA helicaseQuickGO ontologyBLASTP
14770441477214171hypothetical protein
14772221477725504hypothetical proteinBLASTP
147774414789311188aspartate aminotransferaseQuickGO ontologyBLASTP
14790531479760708dna replication protein dnadQuickGO ontologyBLASTP
14797761480423648endonuclease iiiQuickGO ontologyBLASTP
14804271480945519hypothetical proteinBLASTP
148096914836622694penicillin-binding proteinQuickGO ontologyBLASTP