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Query: NC_007530:1459412:1462613 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 1462613, End: 1463293, Length: 681

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005945:1459357:146243214624321463247816Bacillus anthracis str. Sterne, complete genomehypothetical protein6e-93340
NC_015387:1278471:128375912837591284445687Marinithermus hydrothermalis DSM 14884 chromosome, complete genomepeptidase membrane zinc metallopeptidase6e-41167
NC_014761:1196669:120180212018021202488687Oceanithermus profundus DSM 14977 chromosome, complete genomepeptidase membrane zinc metallopeptidase1e-39162
NC_000853:1480478:150756715075671508259693Thermotoga maritima MSB8, complete genomehypothetical protein5e-38157
NC_009012:686740:697480697480698163684Clostridium thermocellum ATCC 27405, complete genomepeptidase, membrane zinc metallopeptidase, putative5e-38157
NC_014657:944000:944976944976945671696Caldicellulosiruptor owensensis OL chromosome, complete genomepeptidase membrane zinc metallopeptidase1e-36153
NC_007512:1459685:147917214791721479873702Pelodictyon luteolum DSM 273, complete genomehypothetical protein4e-32138
NC_002967:2194829:219562321956232196303681Treponema denticola ATCC 35405, complete genomehypothetical protein1e-31136
NC_012225:1657248:167555816755581676268711Brachyspira hyodysenteriae WA1, complete genomeZn dependant metalloprotease5e-30131
NC_017243:424132:425311425311426018708Brachyspira intermedia PWS/A chromosome, complete genomeZn dependent metalloprotease2e-28125
NC_012526:1345597:136109013610901361776687Deinococcus deserti VCD115, complete genomeputative zinc metallopeptidase5e-28124
NC_011831:1693935:171261317126131713320708Chloroflexus aggregans DSM 9485, complete genomepeptidase membrane zinc metallopeptidase putative2e-27122
NC_009613:2697913:270820327082032708901699Flavobacterium psychrophilum JIP02/86, complete genomeM48 family membrane-associated zinc metalloprotease precursor5e-24110
NC_014541:1996811:200943720094372010126690Ferrimonas balearica DSM 9799 chromosome, complete genomepeptidase membrane zinc metallopeptidase putative2e-21102
NC_015581:1791658:179165817916581792356699Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomepeptidase membrane zinc metallopeptidase3e-0755.5