Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2842453 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
284245328445312079transcriptional activator of the formate hydrogenlyase systemQuickGO ontologyBLASTP
28445932844937345hypothetical proteinBLASTP
28451192846036918iron transport protein periplasmic-binding proteinQuickGO ontologyBLASTP
28460332846854822iron transport protein ATP-binding componentQuickGO ontologyBLASTP
28468512847711861iron transport protein inner membrane componentQuickGO ontologyBLASTP
28477022848550849iron transport protein inner membrane componentQuickGO ontologyBLASTP
28485222848731210hypothetical proteinBLASTP
28488272849582756possible AraC-family transcriptional regulatorQuickGO ontologyBLASTP
28499672850854888possible AraC-family transcriptional regulatorQuickGO ontologyBLASTP
28512002851652453hypothetical protein found within S typhi pathogenicity island 1QuickGO ontologyBLASTP
28516682852339672oxygen-regulated invasion proteinQuickGO ontologyBLASTP
28522962852874579oxygen-regulated invasion proteinQuickGO ontologyBLASTP
28528672853625759pathogenicity 1 island effector proteinQuickGO ontologyBLASTP
28536222853927306pathogenicity 1 island effector proteinQuickGO ontologyBLASTP
28539462854188243pathogenicity 1 island effector proteinQuickGO ontologyBLASTP
285421328553911179pathogenicity 1 island effector proteinQuickGO ontologyBLASTP
28557072856636930AraC-family transcriptional regulatorQuickGO ontologyBLASTP
285772328593841662invasion protein regulatorQuickGO ontologyBLASTP
28594022859884483cell invasion proteinQuickGO ontologyBLASTP
285993828615691632tyrosine phosphataseQuickGO ontologyBLASTP
28615562861906351chaperoneQuickGO ontologyBLASTP
28619752862235261hypothetical proteinBLASTP
28622792862527249acyl carrier proteinQuickGO ontologyBLASTP
286254628646032058pathogenicity island 1 effector proteinQuickGO ontologyBLASTP
286462228656441023pathogenicity island 1 effector proteinQuickGO ontologyBLASTP
286571428669431230pathogenicity island 1 effector proteinQuickGO ontologyBLASTP
286697128687521782pathogenicity island 1 effector proteinQuickGO ontologyBLASTP
28687552869252498unknown functionQuickGO ontologyBLASTP
286939028704601071type III secretion proteinQuickGO ontologyBLASTP
28704472871238792virulence-associated secretory proteinQuickGO ontologyBLASTP