Pre_GI Gene

Some Help

Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4314389 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43143894315294906lysR-family transcriptional regulatorQuickGO ontologyBLASTP
431554743167251179hypothetical proteinBLASTP
43167224317216495low molecular weight protein-tyrosine-phosphataseQuickGO ontologyBLASTP
43172224317599378hypothetical proteinBLASTP
43176594317976318hypothetical proteinBLASTP
43181184318330213hypothetical protein
43186484319373726transcriptional regulatorQuickGO ontologyBLASTP
43195014319911411regulatorQuickGO ontologyBLASTP
431996143215021542hypothetical proteinBLASTP
432175643235941839thiamine biosynthesis protein ThiCQuickGO ontologyBLASTP
432444143257931353hypothetical proteinBLASTP
43259904326556567hypothetical proteinBLASTP
43268664327165300hypothetical proteinBLASTP
43275764328355780gntR-family transcriptional regulatorQuickGO ontologyBLASTP
43285214328871351regulatory proteinQuickGO ontologyBLASTP
432887143301721302ftsKspoIIIE family proteinQuickGO ontologyBLASTP
43301694330366198hypothetical proteinBLASTP
433066343320211359plasmid replication initiator proteinQuickGO ontologyBLASTP
433216043336471488integrase recombinaseQuickGO ontologyBLASTP
43337994333930132thiamin biosynthesis protein ThiCQuickGO ontology
433401043354581449hypothetical proteinBLASTP