Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:613798 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
613798614496699capsular polysaccharide biosynthsis proteinQuickGO ontologyBLASTP
614510615163654capsular polysaccharide biosynthsis proteinQuickGO ontologyBLASTP
615362616030669capsular polysaccharide biosynthsis proteinQuickGO ontologyBLASTP
6160516173971347probable NDP-suger dehydrogenaseQuickGO ontologyBLASTP
6174146184601047probable mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
618495619220726N-acetyl-mannosamine transferaseQuickGO ontologyBLASTP
619235619669435hypothetical protein
619663620319657probable hexosyltransferaseQuickGO ontologyBLASTP
6203216214481128probable hexosyltransferaseQuickGO ontologyBLASTP
6214666226951230probable hexosyltransferaseQuickGO ontologyBLASTP
622784623764981capsular polysaccharide biosynthsis proteinQuickGO ontologyBLASTP
6237756248781104probable lipopolysaccharide biosynthesis proteinQuickGO ontologyBLASTP
6248836263671485hypothetical proteinBLASTP
6263876274331047spore coat polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
6274086289281521probable flippaseQuickGO ontologyBLASTP
629121630041921UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
630408631055648hypothetical proteinBLASTP
6314766337192244hypothetical protein
6337976348131017UDP-glucose 4-epimeraseQuickGO ontologyBLASTP
635095636039945UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP