Pre_GI: BLASTP Hits

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Query: NC_009378:62215:61775 Yersinia pestis Pestoides F plasmid MT, complete sequence

Start: 61775, End: 62218, Length: 444

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005815:61148:607086070861151444Yersinia pestis biovar Microtus str. 91001 plasmid pMT1, completehypothetical protein1e-71267
NC_004838:51013:924769247692919444Yersinia pestis KIM plasmid pMT-1, complete sequencehypothetical protein1e-71267
NC_008118:56777:563375633756780444Yersinia pestis Nepal516 plasmid pMT, complete sequencehypothetical protein1e-71267