Pre_GI Gene

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Host: NC_008118 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008118:56777 Yersinia pestis Nepal516 plasmid pMT, complete sequence

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8711091023transposaseQuickGO ontologyBLASTP
11091888780transposaseQuickGO ontologyBLASTP
20222630609hypothetical proteinBLASTP
5633756780444hypothetical proteinBLASTP
56777603013525DNA polymerase IIIQuickGO ontologyBLASTP
60482617171236porphyrin biosynthetic proteinQuickGO ontologyBLASTP
61814641802367porphyrin biosynthetic proteinQuickGO ontologyBLASTP
6429064502213hypothetical proteinBLASTP
6476565151387hypothetical proteinBLASTP
65146662491104integraseQuickGO ontologyBLASTP
6700967521513F1 capsule antigenQuickGO ontologyBLASTP
67602701032502F1 capsule anchoring proteinQuickGO ontologyBLASTP
7012870904777F1 chaperone proteinQuickGO ontologyBLASTP
7121472137924F1 operon positive regulatory proteinQuickGO ontologyBLASTP
7265272957306C-type natriuretic proteinQuickGO ontologyBLASTP
7310373318216hypothetical proteinBLASTP
73478745151038DNA ligaseQuickGO ontologyBLASTP
7459175370780transposaseQuickGO ontologyBLASTP
75370763921023transposaseQuickGO ontologyBLASTP
7640676759354hypothetical proteinBLASTP
7679477270477hypothetical proteinBLASTP
7735278146795hypothetical proteinBLASTP
7839979121723hypothetical proteinBLASTP
79155803631209transposaseQuickGO ontologyBLASTP
80832818541023transposaseQuickGO ontologyBLASTP
8205382340288hypothetical proteinBLASTP
8323083685456hypothetical proteinBLASTP
83930856931764murine toxinQuickGO ontologyBLASTP
8577186259489hypothetical proteinBLASTP
8699887273276hypothetical proteinBLASTP
8729688237942hypothetical proteinBLASTP
8830388923621resolvaseQuickGO ontologyBLASTP
8944989676228hypothetical proteinBLASTP
89978911831206partitioning protein AQuickGO ontologyBLASTP
9118092151972partitioning protein BQuickGO ontologyBLASTP
9228892434147hypothetical proteinBLASTP
92536939271392DNA-binding proteinQuickGO ontologyBLASTP
9408994397309hypothetical proteinBLASTP
9479095467678DNA methylaseQuickGO ontologyBLASTP
9546795688222hypothetical proteinBLASTP
9569996118420hypothetical proteinBLASTP
9617296951780hypothetical proteinBLASTP
9735097856507antirestriction proteinQuickGO ontologyBLASTP
9856998799231hypothetical proteinBLASTP
988721008812010DNA-binding proteinQuickGO ontologyBLASTP