Query: NC_011896:491052 Mycobacterium leprae Br4923, complete genome
Start: 491052, End: 511992, Length: 20941
Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Start | End | Length | Subject Host Description | E-value | Bit score | Visual BLASTN | Visual BLASTP |
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NC_002677:491043 | 491043 | 513273 | 22231 | Mycobacterium leprae TN, complete genome | 0 | 41360 | BLASTN svg | BLASTP svg |
NC_014666:8759873 | 8759873 | 8782874 | 23002 | Frankia sp. EuI1c chromosome, complete genome | 2e-40 | 174 | BLASTN svg | BLASTP svg |
NC_018750:3988196* | 3988196 | 4007325 | 19130 | Streptomyces venezuelae ATCC 10712, complete genome | 4e-36 | 161 | BLASTN svg | BLASTP svg |
NC_021177:4041915* | 4041915 | 4064459 | 22545 | Streptomyces fulvissimus DSM 40593, complete genome | 5e-32 | 147 | BLASTN svg | BLASTP svg |
NC_003155:5253923* | 5253923 | 5276882 | 22960 | Streptomyces avermitilis MA-4680, complete genome | 2e-31 | 145 | BLASTN svg | BLASTP svg |
NC_003888:4251867* | 4251867 | 4306406 | 54540 | Streptomyces coelicolor A3(2), complete genome | 2e-28 | 135 | BLASTN svg | BLASTP svg |
NC_013174:2712000 | 2712000 | 2738033 | 26034 | Jonesia denitrificans DSM 20603, complete genome | 4e-17 | 97.6 | BLASTN svg | BLASTP svg |
NC_013235:1354443 | 1354443 | 1374854 | 20412 | Nakamurella multipartita DSM 44233, complete genome | 4e-17 | 97.6 | BLASTN svg | BLASTP svg |
NC_012704:376783* | 376783 | 402173 | 25391 | Corynebacterium kroppenstedtii DSM 44385, complete genome | 7e-16 | 93.7 | BLASTN svg | BLASTP svg |
NC_008618:200017 | 200017 | 223968 | 23952 | Bifidobacterium adolescentis ATCC 15703, complete genome | 4e-14 | 87.7 | BLASTN svg | BLASTP svg |
NC_019950:3818000 | 3818000 | 3840147 | 22148 | Mycobacterium canettii CIPT 140060008 complete genome | 4e-08 | 67.9 | BLASTN svg | BLASTP svg |
NC_012559:731859 | 731859 | 756303 | 24445 | Laribacter hongkongensis HLHK9, complete genome | 2e-06 | 61.9 | BLASTN svg | BLASTP svg |