Pre_GI: BLASTP Hits

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Query: NC_009565:1629780:1645264 Mycobacterium tuberculosis F11, complete genome

Start: 1645264, End: 1646127, Length: 864

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:1647523:166478016647801665643864Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein8e-133473
NC_016768:2764000:276864927686492769512864Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein1e-132472
NC_002945:1621765:163742616374261638289864Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-132472
NC_014246:1402500:140258214025821403490909Mobiluncus curtisii ATCC 43063 chromosome, complete genomehypothetical protein6e-1065.1
NC_007963:1190847:122554612255461226454909Chromohalobacter salexigens DSM 3043, complete genomehypothetical protein5e-0962