Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:2764000 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
276400127657761776hypothetical proteinBLASTP
27659322766873942antibiotic-transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
27668702767655786antibiotic-transport membrane ABC transporterQuickGO ontologyBLASTP
27677672768699933antibiotic-transport membrane ABC transporterQuickGO ontologyBLASTP
27686492769512864hypothetical proteinBLASTP
27695322770518987quinone reductase qorQuickGO ontologyBLASTP
277054627718441299transcriptional activatorQuickGO ontologyBLASTP
277196027741762217hypothetical proteinBLASTP
27742252775151927cytochrome C oxidase assembly factor ctaBQuickGO ontologyBLASTP
277555027797764227hypothetical proteinBLASTP
278021527823172103transketolase tktQuickGO ontologyBLASTP
278233427834551122transaldolase talQuickGO ontologyBLASTP
278345227849961545glucose-6-phosphate 1-dehydrogenase zwf2QuickGO ontologyBLASTP
27850492785960912oxpp cycle protein opcAQuickGO ontologyBLASTP
278595727867007446-phosphogluconolactonase devBQuickGO ontologyBLASTP