Query: NC_010161:1501758 Bartonella tribocorum CIP 105476, complete genome
D: 31.9674
Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.
Sub Cluster statistics
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Subject Host Description | Proposed Island Flow | Subject Island D |
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NC_020304:1977249 | Desulfocapsa sulfexigens DSM 10523, complete genome | Subject ←→ Query | 27.3468 |
NC_016940:421819 | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 27.6325 |
NC_021175:2063611* | Streptococcus oligofermentans AS 1.3089, complete genome | Subject ←→ Query | 28.6301 |
NC_016940:4326000* | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 29.1869 |
NC_016940:822892* | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 29.3106 |
NC_020300:646500* | Bartonella australis Aust/NH1, complete genome | Subject ←→ Query | 29.3818 |
NC_014650:1763308 | Geobacillus sp. Y4.1MC1 chromosome, complete genome | Subject ←→ Query | 30.6564 |
NC_016940:271500* | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 30.9369 |
NC_016940:3632974 | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 31.0311 |
NC_013960:1319349 | Nitrosococcus halophilus Nc4 chromosome, complete genome | Subject ←→ Query | 31.0737 |
NC_016940:190986* | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 31.577 |
NC_016940:2974396 | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 31.6738 |
NC_010161:1501758* | Bartonella tribocorum CIP 105476, complete genome | Subject ←→ Query | 31.9674 |
NC_020300:1274581 | Bartonella australis Aust/NH1, complete genome | Subject ←→ Query | 32.5511 |
NC_013960:2662458 | Nitrosococcus halophilus Nc4 chromosome, complete genome | Subject ←→ Query | 33.751 |
NC_016940:995500 | Saprospira grandis str. Lewin chromosome, complete genome | Subject ←→ Query | 35.1032 |
NC_007645:1033834* | Hahella chejuensis KCTC 2396, complete genome | Subject ←→ Query | 35.5123 |
NC_007484:130896 | Nitrosococcus oceani ATCC 19707, complete genome | Subject ←→ Query | 35.6153 |
NC_014315:114151 | Nitrosococcus watsoni C-113 chromosome, complete genome | Subject ←→ Query | 36.9613 |
NC_014315:3004125 | Nitrosococcus watsoni C-113 chromosome, complete genome | Subject ←→ Query | 38.6036 |
NC_020409:2856481 | Desulfovibrio piezophilus str. nov C1TLV30 chromosome, complete | Subject ←→ Query | 40.1284 |
NC_010513:542312* | Xylella fastidiosa M12 chromosome, complete genome | Subject ← Query | 42.0784 |
NC_007645:6500059* | Hahella chejuensis KCTC 2396, complete genome | Subject ← Query | 42.9688 |
NC_007645:2408125* | Hahella chejuensis KCTC 2396, complete genome | Subject ← Query | 44.4654 |
NC_007645:2779381* | Hahella chejuensis KCTC 2396, complete genome | Subject ← Query | 45.1313 |
NC_007645:5397526 | Hahella chejuensis KCTC 2396, complete genome | Subject ← Query | 49.0258 |