Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:335160 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3351603365781419DNA stabilization proteinQuickGO ontologyBLASTP
336578337426849putative Chromosome segregation ATPaseQuickGO ontologyBLASTP
337426337881456Gene 10 proteinQuickGO ontologyBLASTP
337884338576693putative DNA transfer proteinQuickGO ontologyBLASTP
3385863400131428putative phage injection proteinQuickGO ontologyBLASTP
3400133420101998Gene 13 proteinQuickGO ontologyBLASTP
342100342393294putative Chromosome segregation ATPaseQuickGO ontologyBLASTP
342492343031540HNH endonucleaseQuickGO ontologyBLASTP
3430893442431155Tail spike proteinQuickGO ontologyBLASTP
344212344805594Tail spike proteinQuickGO ontologyBLASTP
3448723461221251Glucosyl transferaseQuickGO ontologyBLASTP
346150347067918Bactoprenol glucosyl transferaseQuickGO ontologyBLASTP
347064347426363Bactoprenol-linked glucose translocaseQuickGO ontologyBLASTP
347776348240465putative phage integraseQuickGO ontologyBLASTP
348267349085819IS600 ORF2QuickGO ontologyBLASTP
349449350117669IS629 ORF2QuickGO ontologyBLASTP
350414350659246IS629 orfAQuickGO ontologyBLASTP
3508103519251116MASE2 domaindiguanylate cyclaseQuickGO ontologyBLASTP
351942352751810Pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
353512354036525shikimate kinaseQuickGO ontologyBLASTP
354086354277192putative cytoplasmic proteinQuickGO ontologyBLASTP
354535355212678Protein aroMQuickGO ontologyBLASTP
355284355568285protein yaiEQuickGO ontologyBLASTP
355777356058282hypothetical proteinBLASTP
356055356510456hypothetical proteinBLASTP
356588357571984Nonspecific DNA binding proteinQuickGO ontologyBLASTP
3574863585321047Possible NAGC-like transcriptional regulatorQuickGO ontologyBLASTP
3586753599521278Involved in either transport or processing of arabinose polymersQuickGO ontologyBLASTP
3599823631253144ATP-dependent dsDNA exonucleaseQuickGO ontologyBLASTP
3631223643241203ATP-dependent dsDNA exonucleaseQuickGO ontologyBLASTP
364310364441132hypothetical protein