Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2905138 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
290513829069371800hypothetical proteinBLASTP
29071792908000822flagellinQuickGO ontologyBLASTP
29082722908613342hypothetical proteinBLASTP
290864029110782439Flagellar hook-associated protein 2QuickGO ontologyBLASTP
29111322911521390flagellar protein FliSQuickGO ontologyBLASTP
29115582911857300hypothetical proteinBLASTP
29119142912270357flaG family proteinQuickGO ontologyBLASTP
29122862912504219carbon storage regulatorQuickGO ontologyBLASTP
29125042912935432hypothetical proteinBLASTP
29130032913965963flagellar hook-associated protein 3QuickGO ontologyBLASTP
291398329158481866flagellar hook-associated protein FlgKQuickGO ontologyBLASTP
29161252916529405flgN family proteinQuickGO ontologyBLASTP
29165292916810282regulator of flagellin synthesis FlgMQuickGO ontologyBLASTP
291739829185581161flagellar motor switch protein FliNQuickGO ontologyBLASTP
29185512919546996flagellar motor switch protein FliMQuickGO ontologyBLASTP
29195742919969396putative chemotaxis protein CheWQuickGO ontologyBLASTP
29200692920428360chemotaxis protein CheYQuickGO ontologyBLASTP
29204562921055600chemotaxis protein CheCQuickGO ontologyBLASTP
292108129231562076chemotaxis protein CheAQuickGO ontologyBLASTP
29231692923939771chemotaxis protein methyltransferase CheRQuickGO ontologyBLASTP
292395429250181065protein-glutamate methylesterase CheBQuickGO ontologyBLASTP
29250412925529489chemotaxis protein CheDQuickGO ontologyBLASTP
29255462925992447chemotaxis protein CheWQuickGO ontologyBLASTP