Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2635892 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
263589226369831092radical SAM domain-containing proteinQuickGO ontologyBLASTP
26369762637680705ribonuclease IIIQuickGO ontologyBLASTP
26378052638038234acyl carrier proteinQuickGO ontologyBLASTP
263811626391231008fatty acidphospholipid synthesis protein PlsXQuickGO ontologyBLASTP
2639213263939518350S ribosomal protein L32QuickGO ontologyBLASTP
26394092639909501ribosomal protein L32 family proteinQuickGO ontologyBLASTP
264002726412201194acetate kinaseQuickGO ontologyBLASTP
26413582642356999phosphate acetyltransferaseQuickGO ontologyBLASTP
26426902643568879hypothetical proteinBLASTP
26446842644959276hypothetical proteinBLASTP
264496826470822115D-proline reductase subunit PrdAQuickGO ontologyBLASTP
26471172647287171putative electron transport proteinQuickGO ontologyBLASTP
264730926484271119putative electron transport proteinQuickGO ontologyBLASTP
26494202650316897hypothetical proteinBLASTP
265062626526442019methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
26530362653221186rrf2 family proteinQuickGO ontologyBLASTP
265366626547511086hypothetical proteinBLASTP
265482026558961077hypothetical proteinBLASTP
26561132656310198hypothetical proteinBLASTP
265645126578961446amino acid permease family proteinQuickGO ontologyBLASTP
26580492658918870hypothetical proteinBLASTP
265944326604501008proline racemaseQuickGO ontologyBLASTP
26604652660590126PrdA domain proteinQuickGO ontology
26605772660936360PrdA domain proteinQuickGO ontologyBLASTP
26609502661726777glycinesarcosinebetaine reductase component B subunits alpha and betaQuickGO ontologyBLASTP
26628682663143276hypothetical proteinBLASTP
266315226652602109putative D-proline reductase PrdA proproteinQuickGO ontologyBLASTP
26652852665461177putative electron transport proteinQuickGO ontologyBLASTP
266548326666011119putative electron transport proteinQuickGO ontologyBLASTP
26672402667902663hypothetical proteinBLASTP
266794226692461305putative electron transport proteinQuickGO ontologyBLASTP
26692452669361117hypothetical proteinBLASTP
26696782670205528hypothetical proteinBLASTP
26702102670689480hypothetical proteinBLASTP
26711662671594429PrdA domain proteinQuickGO ontologyBLASTP
267311226748661755sensory box sigma-54 dependent transcriptional regulatorQuickGO ontologyBLASTP
267520226764311230hypothetical proteinBLASTP