Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:1 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113381338chromosomal replication initiator protein DnaAQuickGO ontologyBLASTP
160127041104DNA polymerase III subunit betaQuickGO ontologyBLASTP
27232929207S4 domain-containing proteinQuickGO ontologyBLASTP
300841021095DNA replication and repair protein RecFQuickGO ontologyBLASTP
41234386264hypothetical proteinBLASTP
440463171914DNA gyrase subunit BQuickGO ontologyBLASTP
634388022460DNA gyrase subunit AQuickGO ontologyBLASTP
89369052117hypothetical proteinBLASTP
141781425376tRNA-AlaQuickGO ontologyBLASTP
1441814870453hypothetical proteinBLASTP
1488615407522putative transcriptional regulatorQuickGO ontologyBLASTP
15409165721164iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
16577192582682hypothetical proteinBLASTP