Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:4686971 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
468697146889561986hypothetical proteinBLASTP
46892094689526318hypothetical proteinBLASTP
46895954689924330hypothetical proteinBLASTP
46900714690829759carbon-phosphorus lyase complex accessory proteinQuickGO ontologyBLASTP
46908314691265435aminoalkylphosphonic acid N-acetyltransferaseQuickGO ontologyBLASTP
46912524691809558ribose 15-bisphosphokinaseQuickGO ontologyBLASTP
469180946929451137phosphonate metabolism protein PhnMQuickGO ontologyBLASTP
46929424693622681ATP-binding protein of phosphonate transportQuickGO ontologyBLASTP
46937334694491759phosphonate C-P lyase system protein PhnKQuickGO ontologyBLASTP
46944884695333846phosphonate metabolism proteinQuickGO ontologyBLASTP
469532646963901065phosphonate metabolism proteinQuickGO ontologyBLASTP
46963904696974585carbon-phosphorus lyase complex subunitQuickGO ontologyBLASTP
46969714697423453carbon-phosphorus lyase complex subunitQuickGO ontologyBLASTP
46974244698149726phosphonate metabolism transcriptional regulator PhnFQuickGO ontologyBLASTP
46981704698949780membrane channel protein component of Pn transporterQuickGO ontologyBLASTP
469907547000911017periplasmic binding protein component of Pn transporterQuickGO ontologyBLASTP
47001164700904789phosphonateorganophosphate ester transporter subunitQuickGO ontologyBLASTP
47011184701480363hypothetical proteinBLASTP
47016384701973336putative alkylphosphonate uptake protein in phosphonate metabolismQuickGO ontologyBLASTP
470237547046032229hypothetical proteinBLASTP
47046004705466867hypothetical proteinBLASTP