Pre_GI Gene

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Host: NC_012973 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012973:49208 Helicobacter pylori B38 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4851349211699type II adenine methyltransferaseQuickGO ontologyBLASTP
50353518431491Symporter SSS family Proline Permease membrane proteinQuickGO ontologyBLASTP
51870554273558bifunctional proline dehydrogenasedelta-1-pyrroline-5-carboxylate dehydrogenaseQuickGO ontologyBLASTP
5575655965210hypothetical proteinBLASTP
5628857265978hypothetical proteinBLASTP
5726658111846hypothetical proteinBLASTP
6053461103570hypothetical proteinBLASTP
6111961379261hypothetical proteinBLASTP
61390630991710hypothetical proteinBLASTP
6313263494363hypothetical proteinBLASTP
6349663843348hypothetical proteinBLASTP
6633767134798urease accessory protein UreHQuickGO ontologyBLASTP
6713467733600urease accessory protein UreGQuickGO ontologyBLASTP
6776268532771urease accessory protein UreFQuickGO ontologyBLASTP
6855669068513urease accessory protein UreEQuickGO ontologyBLASTP
6907069657588urease accessory protein UreIQuickGO ontologyBLASTP
69850715591710urease subunit betaQuickGO ontologyBLASTP
7156372279717urease subunit alphaQuickGO ontologyBLASTP