Pre_GI: OUP Neighbours

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Query: NC_012973:49208 Helicobacter pylori B38 chromosome, complete genome

D: 19.054

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

Number of Neighbours: 194

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_017366:1055319*Helicobacter pylori F32, complete genome78.4283 %Subject ←→ Query19.3397
NC_011498:1571840Helicobacter pylori P12, complete genome84.6293 %Subject ←→ Query19.8717
NC_018939:1583653Helicobacter pylori 26695 chromosome, complete genome85.4871 %Subject ←→ Query19.949
NC_012973:967380Helicobacter pylori B38 chromosome, complete genome81.1857 %Subject ←→ Query20.0403
NC_014555:47372Helicobacter pylori PeCan4 chromosome, complete genome93.3333 %Subject ←→ Query20.197
NC_000915:53715Helicobacter pylori 26695, complete genome92.7451 %Subject ←→ Query20.2152
NC_018939:53715Helicobacter pylori 26695 chromosome, complete genome92.7359 %Subject ←→ Query20.2152
NC_017367:1505780*Helicobacter pylori F57, complete genome85.8395 %Subject ←→ Query20.2456
NC_017362:992293Helicobacter pylori Lithuania75 chromosome, complete genome79.277 %Subject ←→ Query20.2912
NC_017378:986611Helicobacter pylori Puno120 chromosome, complete genome81.6912 %Subject ←→ Query20.3429
NC_018939:454000Helicobacter pylori 26695 chromosome, complete genome81.5043 %Subject ←→ Query20.4645
NC_017355:997089Helicobacter pylori v225d chromosome, complete genome80.5515 %Subject ←→ Query20.4784
NC_014555:1477934*Helicobacter pylori PeCan4 chromosome, complete genome86.0386 %Subject ←→ Query20.7685
NC_017359:813500Helicobacter pylori Sat464 chromosome, complete genome81.5993 %Subject ←→ Query20.9371
NC_017375:1317398*Helicobacter pylori 83 chromosome, complete genome81.4308 %Subject ←→ Query21.0664
NC_017354:1465925*Helicobacter pylori 52 chromosome, complete genome86.0846 %Subject ←→ Query21.1302
NC_017365:1466500*Helicobacter pylori F30, complete genome83.8388 %Subject ←→ Query21.1355
NC_017378:1489818*Helicobacter pylori Puno120 chromosome, complete genome85.8854 %Subject ←→ Query21.2062
NC_017361:930280*Helicobacter pylori SouthAfrica7 chromosome, complete genome81.2132 %Subject ←→ Query21.4337
NC_017360:1052473*Helicobacter pylori 35A chromosome, complete genome81.6605 %Subject ←→ Query21.4344
NC_017372:902043*Helicobacter pylori India7 chromosome, complete genome85.0306 %Subject ←→ Query21.4433
NC_017378:1518529Helicobacter pylori Puno120 chromosome, complete genome80.7996 %Subject ←→ Query21.4852
NC_017371:1030148Helicobacter pylori Gambia94/24 chromosome, complete genome83.7929 %Subject ←→ Query21.5743
NC_017367:278916Helicobacter pylori F57, complete genome82.0374 %Subject ←→ Query21.7822
NC_014555:1526775Helicobacter pylori PeCan4 chromosome, complete genome81.1826 %Subject ←→ Query21.8455
NC_017362:1512959Helicobacter pylori Lithuania75 chromosome, complete genome80.2849 %Subject ←→ Query21.8502
NC_014560:53750Helicobacter pylori SJM180 chromosome, complete genome92.5613 %Subject ←→ Query21.9905
NC_014256:448710Helicobacter pylori B8 chromosome, complete genome81.3634 %Subject ←→ Query22.0728
NC_017368:852490*Helicobacter pylori F16, complete genome81.6238 %Subject ←→ Query22.1065
NC_017381:982216Helicobacter pylori 2018 chromosome, complete genome81.4369 %Subject ←→ Query22.1098
NC_017357:973392Helicobacter pylori 908 chromosome, complete genome84.4026 %Subject ←→ Query22.1512
NC_018939:1044000Helicobacter pylori 26695 chromosome, complete genome79.3352 %Subject ←→ Query22.1555
NC_014560:171931*Helicobacter pylori SJM180 chromosome, complete genome86.0754 %Subject ←→ Query22.2094
NC_017365:848500*Helicobacter pylori F30, complete genome81.6115 %Subject ←→ Query22.2678
NC_017376:538000Helicobacter pylori SNT49 chromosome, complete genome79.3689 %Subject ←→ Query22.3371
NC_017374:974279Helicobacter pylori 2017 chromosome, complete genome80.5576 %Subject ←→ Query22.3751
NC_017355:1299874*Helicobacter pylori v225d chromosome, complete genome82.5153 %Subject ←→ Query22.3918
NC_014256:683384*Helicobacter pylori B8 chromosome, complete genome83.3977 %Subject ←→ Query22.4101
NC_014560:1366747Helicobacter pylori SJM180 chromosome, complete genome82.1722 %Subject ←→ Query22.4172
NC_017361:1303553*Helicobacter pylori SouthAfrica7 chromosome, complete genome82.8431 %Subject ←→ Query22.4343
NC_017355:493237*Helicobacter pylori v225d chromosome, complete genome78.0423 %Subject ←→ Query22.497
NC_011333:1236730*Helicobacter pylori G27 chromosome, complete genome82.7053 %Subject ←→ Query22.505
NC_017063:834674Helicobacter pylori ELS37 chromosome, complete genome79.6232 %Subject ←→ Query22.5255
NC_017063:775337*Helicobacter pylori ELS37 chromosome, complete genome85.4534 %Subject ←→ Query22.6411
NC_017376:57500Helicobacter pylori SNT49 chromosome, complete genome82.1998 %Subject ←→ Query22.6458
NC_017354:848500*Helicobacter pylori 52 chromosome, complete genome81.7096 %Subject ←→ Query22.7001
NC_017367:562918Helicobacter pylori F57, complete genome79.2678 %Subject ←→ Query22.7778
NC_018939:547793Helicobacter pylori 26695 chromosome, complete genome77.9259 %Subject ←→ Query22.8113
NC_017361:1528239Helicobacter pylori SouthAfrica7 chromosome, complete genome80.8609 %Subject ←→ Query22.851
NC_017375:872478*Helicobacter pylori 83 chromosome, complete genome81.3726 %Subject ←→ Query22.9485
NC_017379:996500Helicobacter pylori Puno135 chromosome, complete genome80.7537 %Subject ←→ Query23.0394
NC_017358:220900Helicobacter pylori Cuz20 chromosome, complete genome81.6299 %Subject ←→ Query23.078
NC_014560:1309470*Helicobacter pylori SJM180 chromosome, complete genome83.9737 %Subject ←→ Query23.0849
NC_017378:502806Helicobacter pylori Puno120 chromosome, complete genome78.5754 %Subject ←→ Query23.0891
NC_017371:530673Helicobacter pylori Gambia94/24 chromosome, complete genome79.2218 %Subject ←→ Query23.1308
NC_017379:1233482*Helicobacter pylori Puno135 chromosome, complete genome85.6648 %Subject ←→ Query23.2065
NC_011333:514464Helicobacter pylori G27 chromosome, complete genome78.5907 %Subject ←→ Query23.2936
NC_014560:518582*Helicobacter pylori SJM180 chromosome, complete genome81.7188 %Subject ←→ Query23.2968
NC_011498:1345623*Helicobacter pylori P12, complete genome83.9798 %Subject ←→ Query23.322
NC_017357:495213Helicobacter pylori 908 chromosome, complete genome81.5993 %Subject ←→ Query23.3524
NC_011333:1040192*Helicobacter pylori G27 chromosome, complete genome82.2549 %Subject ←→ Query23.376
NC_017371:1470582*Helicobacter pylori Gambia94/24 chromosome, complete genome79.5864 %Subject ←→ Query23.3827
NC_017358:563336Helicobacter pylori Cuz20 chromosome, complete genome79.3107 %Subject ←→ Query23.4728
NC_017379:505350Helicobacter pylori Puno135 chromosome, complete genome79.2402 %Subject ←→ Query23.5439
NC_017358:1342000*Helicobacter pylori Cuz20 chromosome, complete genome83.606 %Subject ←→ Query23.5469
NC_014256:636000*Helicobacter pylori B8 chromosome, complete genome85.7659 %Subject ←→ Query23.553
NC_017371:1601452*Helicobacter pylori Gambia94/24 chromosome, complete genome85.5974 %Subject ←→ Query23.6245
NC_014256:485969Helicobacter pylori B8 chromosome, complete genome78.2567 %Subject ←→ Query23.6492
NC_017379:1035464Helicobacter pylori Puno135 chromosome, complete genome81.106 %Subject ←→ Query23.6756
NC_017375:77142Helicobacter pylori 83 chromosome, complete genome77.5643 %Subject ←→ Query23.6929
NC_000921:1343701*Helicobacter pylori J99, complete genome81.8107 %Subject ←→ Query23.6929
NC_017366:535188Helicobacter pylori F32, complete genome77.883 %Subject ←→ Query23.9333
NC_017358:182854*Helicobacter pylori Cuz20 chromosome, complete genome75.8333 %Subject ←→ Query24.0093
NC_017063:800156Helicobacter pylori ELS37 chromosome, complete genome79.4761 %Subject ←→ Query24.0797
NC_017374:498588Helicobacter pylori 2017 chromosome, complete genome79.0656 %Subject ←→ Query24.1336
NC_017381:500699Helicobacter pylori 2018 chromosome, complete genome78.9798 %Subject ←→ Query24.1686
NC_017372:855384*Helicobacter pylori India7 chromosome, complete genome81.8873 %Subject ←→ Query24.1732
NC_017362:506950Helicobacter pylori Lithuania75 chromosome, complete genome78.701 %Subject ←→ Query24.4401
NC_017372:748097Helicobacter pylori India7 chromosome, complete genome78.6458 %Subject ←→ Query24.6808
NC_017371:1358000*Helicobacter pylori Gambia94/24 chromosome, complete genome82.9657 %Subject ←→ Query24.6899
NC_017365:77150*Helicobacter pylori F30, complete genome81.3143 %Subject ←→ Query24.696
NC_017063:1362000*Helicobacter pylori ELS37 chromosome, complete genome80.5055 %Subject ←→ Query24.921
NC_014555:502151Helicobacter pylori PeCan4 chromosome, complete genome78.7714 %Subject ←→ Query24.9588
NC_017378:1175639*Helicobacter pylori Puno120 chromosome, complete genome84.3168 %Subject ←→ Query24.9757
NC_017376:1324000*Helicobacter pylori SNT49 chromosome, complete genome83.1005 %Subject ←→ Query25.0669
NC_017372:1373766*Helicobacter pylori India7 chromosome, complete genome83.9982 %Subject ←→ Query25.1034
NC_017372:1212000*Helicobacter pylori India7 chromosome, complete genome75.9835 %Subject ←→ Query25.3379
NC_000921:1147394Helicobacter pylori J99, complete genome83.5325 %Subject ←→ Query25.3465
NC_017368:1300000*Helicobacter pylori F16, complete genome82.7022 %Subject ←→ Query25.7174
NC_017375:1498000Helicobacter pylori 83 chromosome, complete genome82.5766 %Subject ←→ Query26.3679
NC_008229:118000*Helicobacter acinonychis str. Sheeba, complete genome79.5466 %Subject ←→ Query26.5139
NC_017367:1333811*Helicobacter pylori F57, complete genome83.9369 %Subject ←→ Query26.6233
NC_017368:468934Helicobacter pylori F16, complete genome78.364 %Subject ←→ Query28.2271
NC_014810:9081Helicobacter felis ATCC 49179, complete genome79.0502 %Subject Query30.1131
NC_015674:1114915Helicobacter bizzozeronii CIII-1, complete genome76.5227 %Subject Query30.3076
NC_015674:1605923Helicobacter bizzozeronii CIII-1, complete genome79.375 %Subject Query31.6766
NC_015674:1562968*Helicobacter bizzozeronii CIII-1, complete genome75.1103 %Subject Query37.5085