Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:5006219 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
500621950087862568hypothetical proteinBLASTP
50087835009046264hypothetical proteinBLASTP
500929950105971299glycosyl transferase group 1 familyQuickGO ontologyBLASTP
501054850117891242glycosyl transferase group 1 familyQuickGO ontologyBLASTP
501208350130841002rod shape-determining protein MblQuickGO ontologyBLASTP
50132465013644399stage III sporulation protein DQuickGO ontologyBLASTP
50139235014303381putative lipoproteinQuickGO ontologyBLASTP
50144595014593135hypothetical proteinBLASTP
50147355015640906stage II sporulation proteinQuickGO ontologyBLASTP
50158025016506705putative ABC transporter permease proteinQuickGO ontologyBLASTP
50165065017348843ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
501866550196841020stage II sporulation protein DQuickGO ontologyBLASTP
501989250211961305UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50212365021940705hypothetical proteinBLASTP
50219925022228237hypothetical proteinBLASTP
502259450241141521NADH dehydrogenase subunit NQuickGO ontologyBLASTP
502411650256091494NADH dehydrogenase subunit MQuickGO ontologyBLASTP
502560650274681863NADH dehydrogenase subunit LQuickGO ontologyBLASTP
50274985027812315NADH dehydrogenase subunit KQuickGO ontologyBLASTP
50278055028329525NADH dehydrogenase subunit JQuickGO ontologyBLASTP
50283265028745420NADH dehydrogenase subunit IQuickGO ontologyBLASTP
502877150297721002NADH dehydrogenase subunit HQuickGO ontologyBLASTP
502977250308721101NADH dehydrogenase subunit DQuickGO ontologyBLASTP