Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:2715651 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27156512716499849hypothetical proteinBLASTP
27201542720720567TetR family transcriptional regulatorQuickGO ontologyBLASTP
272099027221471158acetyltransferase GNAT familyQuickGO ontologyBLASTP
2722333272362212903-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
272363927247391101prephenate dehydrogenaseQuickGO ontologyBLASTP
272473227258321101histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
272585127270231173chorismate synthaseQuickGO ontologyBLASTP
272730827283841077bifunctional 3-deoxy-7-phosphoheptulonate synthasechorismate mutaseQuickGO ontologyBLASTP
27328762733313438hypothetical proteinBLASTP
27334622733992531isochorismatase family proteinQuickGO ontologyBLASTP
27340092734542534acetyltransferase GNAT familyQuickGO ontologyBLASTP
27345622734861300hypothetical proteinBLASTP
27349632735478516hypothetical proteinBLASTP
273553027368521323hypothetical proteinBLASTP
27371902738188999hypothetical proteinBLASTP
27381782738756579RNA polymerase sigma factorQuickGO ontologyBLASTP