Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:709234 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
709234710127894SerThr protein phosphatase family proteinQuickGO ontologyBLASTP
710127710270144hypothetical proteinBLASTP
7103247114061083extracellular exochitinase Chi36QuickGO ontologyBLASTP
7117807131741395GABA permeaseQuickGO ontologyBLASTP
713286713627342hypothetical proteinBLASTP
713647713763117hypothetical proteinBLASTP
713942714481540hypothetical proteinBLASTP
714598715035438NADH-dependent butanol dehydrogenase AQuickGO ontologyBLASTP
715032715760729iron-containing alcohol dehydrogenaseQuickGO ontologyBLASTP
715920716672753DeoR family transcriptional regulatorQuickGO ontologyBLASTP
7166697175809121-phosphofructokinaseQuickGO ontologyBLASTP
7175947194741881PTS system fructose-specific transporter subunit IIABCQuickGO ontologyBLASTP
719822720754933hypothetical proteinBLASTP
720817721062246hypothetical proteinBLASTP
721244722197954tRNA delta2-isopentenylpyrophosphate transferaseQuickGO ontologyBLASTP
722219722443225RNA-binding protein HfqQuickGO ontologyBLASTP
7225247239601437hypothetical proteinBLASTP
724074725039966phage integrase family site-specific recombinaseQuickGO ontologyBLASTP
725153726109957stage V sporulation protein KQuickGO ontologyBLASTP
726378727001624hypothetical proteinBLASTP
7270917281551065GTP-binding protein HflXQuickGO ontologyBLASTP
728152728364213GTP-binding proteinQuickGO ontologyBLASTP
7283577296281272aluminum resistance proteinQuickGO ontologyBLASTP
729804730193390transcriptional repressor GlnRQuickGO ontologyBLASTP
7302427315761335glutamine synthetase type IQuickGO ontologyBLASTP
731691732320630phage integrase phage integrase familyQuickGO ontologyBLASTP