Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:2885519 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28847672885525759imidazole glycerol phosphate synthase subunit HisFQuickGO ontologyBLASTP
288551928862387201-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
28862112886840630imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
28868412887425585imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
288742528887141290histidinol dehydrogenaseQuickGO ontologyBLASTP
28887262889361636ATP phosphoribosyltransferase catalytic subunitQuickGO ontologyBLASTP
288933728905991263ATP phosphoribosyltransferase regulatory subunitQuickGO ontologyBLASTP
28909102891491582isopropylmalate isomerase small subunitQuickGO ontologyBLASTP
289146928928631395isopropylmalate isomerase large subunitQuickGO ontologyBLASTP
2892863289392710653-isopropylmalate dehydrogenaseQuickGO ontologyBLASTP
2894005289552515212-isopropylmalate synthaseQuickGO ontologyBLASTP
289552728965371011ketol-acid reductoisomeraseQuickGO ontologyBLASTP
28965642897073510acetolactate synthase 3 regulatory subunitQuickGO ontologyBLASTP
289707028987791710acetolactate synthase catalytic subunitQuickGO ontologyBLASTP
28990862899982897branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP
29001022900338237hypothetical proteinBLASTP
29003982900637240hypothetical proteinBLASTP
29007552901003249hypothetical proteinBLASTP
29013562901469114hypothetical proteinBLASTP
29015542902021468hypothetical proteinBLASTP
29022542902619366hypothetical proteinBLASTP
290265329039961344TrkH family potassium uptake proteinQuickGO ontologyBLASTP
290519329064281236protonglutamate symporter family proteinQuickGO ontologyBLASTP
29064512906606156hypothetical protein
29067432907138396MarR family transcriptional regulatorQuickGO ontologyBLASTP
29073252907756432hypothetical protein
29078232908377555hypothetical proteinBLASTP