Pre_GI Gene

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Host: NC_012581 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012581:1505276 Bacillus anthracis str. CDC 684 chromosome, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15052761505713438hypothetical proteinBLASTP
15058931506870978hypothetical proteinBLASTP
150682515093742550hypothetical proteinBLASTP
151020615112821077bifunctional 3-deoxy-7-phosphoheptulonate synthasechorismate mutaseQuickGO ontologyBLASTP
151156715127391173chorismate synthaseQuickGO ontologyBLASTP
151275815138581101histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
151385115149511101prephenate dehydrogenaseQuickGO ontologyBLASTP
1514968151625712903-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
151644315176001158GNAT family acetyltransferaseQuickGO ontologyBLASTP
15178701518436567TetR family transcriptional regulatorQuickGO ontologyBLASTP
151869015211132424membrane protein MmpL familyQuickGO ontologyBLASTP
15211141521266153membrane protein MmpL familyQuickGO ontologyBLASTP
15213081521805498hypothetical proteinBLASTP
15220911522939849hypothetical proteinBLASTP
152331715249421626ABC transporter ATP-binding proteinQuickGO ontologyBLASTP