Pre_GI Gene

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Host: NC_012579 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012579:1 Bacillus anthracis str. CDC 684 plasmid pX01, complete sequence

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
207635429hypothetical proteinBLASTP
8891032144hypothetical proteinBLASTP
12211334114hypothetical proteinBLASTP
13521990639hypothetical proteinBLASTP
20072240234hypothetical proteinBLASTP
25163100585hypothetical proteinBLASTP
30843698615hypothetical proteinBLASTP
37494384636hypothetical proteinBLASTP
43845013630hypothetical proteinBLASTP
53496062714hypothetical proteinBLASTP
60796786708hypothetical proteinBLASTP
690387111809reverse transcriptaseendonuclease proteinQuickGO ontologyBLASTP
9315119482634hypothetical proteinBLASTP
1197212199228hypothetical proteinBLASTP
12215133061092hypothetical proteinBLASTP
1340913546138hypothetical proteinBLASTP
1356813981414hypothetical proteinBLASTP
1458415288705hypothetical proteinBLASTP
15399193613963hypothetical proteinBLASTP
19425211191695hypothetical proteinBLASTP
2127821397120hypothetical proteinBLASTP
2150421938435hypothetical proteinBLASTP