Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:1348500 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13487821349408627transcriptional regulator GntR familyQuickGO ontologyBLASTP
13495191350019501hypothetical proteinBLASTP
13503181350878561pncA family proteinQuickGO ontologyBLASTP
13510371351348312rhodanese domain proteinQuickGO ontologyBLASTP
13514241351888465hypothetical proteinBLASTP
13521651352365201hypothetical proteinBLASTP
13525431353454912tetratricopeptide repeat family proteinQuickGO ontologyBLASTP
13536151354187573xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
13544851355066582hypothetical proteinBLASTP
135536213567441383putative thiosulfate sulfurtransferaseQuickGO ontologyBLASTP
13569431357365423hypothetical proteinBLASTP
135770913588121104putative transporterQuickGO ontologyBLASTP
13589921359321330MazG family proteinQuickGO ontologyBLASTP
135945813611971740hypothetical proteinBLASTP
13613361361503168hypothetical proteinBLASTP
13617751361915141hypothetical proteinBLASTP
136209713632961200hypothetical proteinBLASTP
136368913647351047ABC transporter substrate-binding proteinQuickGO ontologyBLASTP
136473713664251689ABC transporter permease proteinQuickGO ontologyBLASTP
13663881367323936ABC transporter ATP-binding proteinQuickGO ontologyBLASTP