Pre_GI Gene

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Host: NC_011527 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011527:1443076 Coxiella burnetii CbuG_Q212, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
144163514430891455chlorohydrolasedeaminase family proteinQuickGO ontologyBLASTP
14430761443975900hydroxymethylglutaryl-CoA lyaseQuickGO ontologyBLASTP
14440051444613609DedA family proteinQuickGO ontologyBLASTP
144467314466912019excinuclease ABC subunit BQuickGO ontologyBLASTP
144668514479561272aspartate aminotransferaseQuickGO ontologyBLASTP
1448011144808676tRNA-AsnQuickGO ontologyBLASTP
14552301455526297hypothetical proteinBLASTP
14568771456981105hypothetical proteinBLASTP
14571411457242102hypothetical proteinBLASTP
14572611457416156hypothetical protein
14576701457771102hypothetical proteinBLASTP
145795314595421590ankyrin repeat proteinQuickGO ontologyBLASTP
1459742145983493hypothetical proteinBLASTP
14603031460419117hypothetical proteinBLASTP
146120214623741173hypothetical proteinBLASTP
14623711462508138metal-dependent amidaseaminoacylasecarboxypeptidaseQuickGO ontologyBLASTP