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Query: NC_011527:1443076:1457953 Coxiella burnetii CbuG_Q212, complete genome

Start: 1457953, End: 1459542, Length: 1590

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011528:1282691:1297578129757812991701593Coxiella burnetii CbuK_Q154, complete genomeankyrin repeat protein0988
NC_009727:1542000:1559453155945315608591407Coxiella burnetii Dugway 7E9-12, complete genomeankyrin repeat protein1e-131470
NC_009727:1542000:155882415588241559069246Coxiella burnetii Dugway 7E9-12, complete genomehypothetical protein5e-40166
NC_010981:425387:4416724416724443922721Wolbachia pipientis, complete genomeankyrin repeat domain protein3e-1583.6
NC_010830:384812:3939843939844012257242Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein1e-1378.6
NC_012225:236490:2453332453332465861254Brachyspira hyodysenteriae WA1, complete genomeankyrin repeat-containing protein1e-1378.2
NC_010830:1543548:1559614155961415610321419Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein2e-1274.3
NC_010830:1836984:1842930184293018476874758Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein8e-1272.4
NC_017243:1323870:133469413346941335446753Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein1e-1068.2
NC_010830:1543548:1551922155192215561304209Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein4e-1066.6
NC_010830:1543548:1568697156869715724463750Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein1e-0758.5
NC_009727:1001203:1003153100315310056752523Coxiella burnetii Dugway 7E9-12, complete genomeankyrin repeat protein1e-0758.5
NC_002971:951102:9676669676669700082343Coxiella burnetii RSA 493, complete genomeankyrin repeat domain protein3e-0757.4
NC_010830:1543548:155901415590141559579566Candidatus Amoebophilus asiaticus 5a2, complete genome3e-0757
NC_009483:739010:7527927527927543061515Geobacter uraniireducens Rf4 chromosome, complete genomeankyrin repeat-containing protein3e-0757
NC_010830:1069666:1075078107507810772492172Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein9e-0755.5
NC_012225:1213421:123595312359531236408456Brachyspira hyodysenteriae WA1, complete genomeankyrin repeat-containing protein1e-0655.1
NC_007109:401500:4044764044764080153540Rickettsia felis URRWXCal2, complete genomeGuanosine polyphosphate pyrophosphohydrolase/synthetase homolog7e-0652.8
NC_010830:632978:63933163933165295313623Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein7e-0652.4