Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:1999500 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
199976020009861227stage IV sporulation protein BQuickGO ontologyBLASTP
20014092002305897homoserine O-succinyltransferaseQuickGO ontologyBLASTP
200233220035581227homoserine dehydrogenaseQuickGO ontologyBLASTP
200359820048781281O-acetylhomoserine aminocarboxypropyltransferasecysteine synthase family proteinQuickGO ontologyBLASTP
200517720068801704DNA repair protein recNQuickGO ontologyBLASTP
20068932007345453arginine repressorQuickGO ontologyBLASTP
20073472008192846ATP-NAD kinaseQuickGO ontologyBLASTP
20081922009013822hemolysin AQuickGO ontologyBLASTP
2009035201090318691-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
20109042011473570hypothetical proteinBLASTP
20122762013148873geranyltranstransferaseQuickGO ontologyBLASTP
20132732013488216exodeoxyribonuclease VII small subunitQuickGO ontologyBLASTP
201360520148161212exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
20148872015318432N utilization substance protein BQuickGO ontologyBLASTP
20154572015852396alkaline shock proteinQuickGO ontologyBLASTP
20159342016458525stage III sporulation protein AHQuickGO ontologyBLASTP
20165202017116597stage III sporulation protein AGQuickGO ontologyBLASTP
20172552017845591stage III sporulation protein AFQuickGO ontologyBLASTP