Pre_GI Gene

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Host: NC_010117 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010117:1633447 Coxiella burnetii RSA 331, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16334471633992546opacity family porin proteinQuickGO ontologyBLASTP
16348051635710906ribosomal protein S6 modification proteinQuickGO ontologyBLASTP
163571316367411029succinylglutamate desuccinylaseaspartoacylase family proteinQuickGO ontologyBLASTP
16391801639365186hypothetical protein
16393911639789399hypothetical proteinBLASTP
16400871640425339hypothetical proteinBLASTP
164044916419001452ankyrin repeat proteinQuickGO ontologyBLASTP
16424801642635156hypothetical proteinBLASTP
16431841643339156hypothetical proteinBLASTP
16439081644510603hypothetical proteinBLASTP
16446821645125444hypothetical proteinBLASTP
16458281646127300conserved domain proteinQuickGO ontologyBLASTP
16465721646709138hypothetical proteinBLASTP
164672416497353012IcmB proteinQuickGO ontologyBLASTP
16498081650443636IcmJ proteinQuickGO ontologyBLASTP
16504591650875417IcmD proteinQuickGO ontologyBLASTP
16509701651479510IcmC proteinQuickGO ontologyBLASTP
16515501652284735IcmG proteinQuickGO ontologyBLASTP
165230216554063105IcmE proteinQuickGO ontologyBLASTP
165540816564451038IcmK proteinQuickGO ontologyBLASTP